hrp0086p2-p571 | Perinatal Endocrinology P2 | ESPE2016

The Effects of Serum Insulin, Leptin, Ghrelin, Adiponectin and Resistin Levels on Early Postnatal Growth in Small for Gestational Age Newborns

Orbak Zerrin , Kara Mustafa

Background: Adipose tissue acts as an endocrine organ, secreting biologically active molecules in response to external stimuli or lipid overloading. These adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin (4). On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between weight gain and serum...

hrp0086p2-p579 | Perinatal Endocrinology P2 | ESPE2016

The Effects of Serum Leptin, Ghrelin, Adiponectin and Resistin Levels on Early Postnatal Growth in Infants of Diabetic Mothers

Kara Mustafa , Orbak Zerrin

Background: The exact mechanisms on growth are not fully eluciated, but they involve insulin resistance, fetal hyperleptinemia, hypothalamic changes. The adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin. On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.Objective and hypotheses: This study aimed to investigate the relation between growth and serum insulin, ...

hrp0082p3-d1-707 | Diabetes | ESPE2014

The Lung Endothelin System: a Potent Therapeutic Target with Bosentan for the Amelioration of Lung Alterations in a Rat Model of Diabetes Mellitus

Cayir Atilla , Halici Zekai , Akpinar Erol , Bayraktutan Zafer , Kara Mustafa

Background: Endothelial dysfunction underlies lung and other organ complications developing in associated with diabetes. Endothelial dysfunction leads to an increase in cytokine levels and oxidative stress. Studies have shown that the endothelin plays significant roles in the development of diabetic complications.Objective and hypotheses: The aim of this study is to show the effect of a new mechanism on endothelin receptors in the physiopathology of diab...